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Mitochondria-Driven Tumorigenesis: A New View of Cancer Metabolism

Are mitochondria active drivers of cancer development rather than secondary players? This article highlights a scientific review proposing that mitochondrial bioenergetics and redox signaling may play a central role in tumorigenesis and cancer therapy strategies.
Mitochondria role in cancer metabolism tumorigenesis concept

Mitochondria are increasingly recognized as regulators of cellular metabolism, immune signaling, and redox balance. This review explores how mitochondrial reprogramming may actively drive tumor development and influence responses to immunotherapy.

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Brain microglia mitochondria dysfunction neuroinflammation concept
Mitochondria

When Microglia Can’t Clean Up Their Mitochondria

Can damaged mitochondria trap the brain in chronic inflammation and drive depression?
This article explores how mitochondria–lysosome crosstalk failure locks microglia into a self-sustaining inflammatory loop, and how this mechanism connects to sepsis, T cell dysfunction, and the IRG1–itaconate axis.

March 31, 2026
Diagram linking thermodynamics and mitochondrial function
Mitochondria

Thermodynamics and Mitochondria

How do the laws of thermodynamics shape mitochondrial function and influence health and disease?
This article examines how fundamental physical laws govern cellular energetics, explaining mitochondrial electron flow, membrane potential, free energy and redox balance, and their implications for inflammation, adaptation and chronic disease.

February 25, 2026
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