Mitochondria are increasingly recognized as regulators of cellular metabolism, immune signaling, and redox balance. This review explores how mitochondrial reprogramming may actively drive tumor development and influence responses to immunotherapy.

Mitochondria
When Microglia Can’t Clean Up Their Mitochondria
Can damaged mitochondria trap the brain in chronic inflammation and drive depression?
This article explores how mitochondria–lysosome crosstalk failure locks microglia into a self-sustaining inflammatory loop, and how this mechanism connects to sepsis, T cell dysfunction, and the IRG1–itaconate axis.


